This article proposes that Māori perspectives and values (tikanga) need to be incorporated when new health technologies become available. The study weaves together the idea of two worlds somewhat like the model of DNA, with two strands moving in parallel, sometimes intersecting and sometimes standing at a distance. Using a kaupapa Māori approach to research, a sample of Māori cultural commentators (pukenga), Māori whānau and health professionals who work with families (interfacers) were interviewed. The results suggest pathways forward in the area of genetic counselling and other services. While these pathways are relevant to Māori and the New Zealand context, the study shows how other cultural groups with alternative world views may seek their own solutions and responses to the technologies available through predictive/pre-symptomatic DNA testing.