Indigenous peoples throughout the world are under considerable cultural and ecological pressure in the face of a rapidly warming world. While contexts and Indigenous knowledge systems are specific, there is much that can be learned from knowledge exchange and collaborations with other Indigenous communities. This article reports on a growing conversation across diverse cultural biospheres (Aotearoa New Zealand, Turtle Island, and Alba/Scotland) regarding inclusive Indigenous-led strategies of multigenerational resilience addressing human-environmental wellbeing. Drawing on indigenist research methodologies, it integrates recent research pertaining to each geo-cultural context, with online international Wisdom Councils collectively participated in by the three regions. Māori systems of healing, Anishinaabe renewable energy-harvesting protocols, and Gàidheil “cultural darning and mending” climate challenge strategies are discussed, including the potential of their cross-context relevance. Attention to non-binary ways of conceptualising Indigenous identities (human and more- than-human), including attention to diverse gender and sexual identities within Indigenous-led climate emergency responsiveness, are also discussed as a critical cross-cutting strategy.