Sir Hirini Moko Mead’s Five Tests framework helps identify a te ao Māori response to contemporary challenges. One such issue that Mead confronted, more than two decades ago, was genetic modification. We applied Mead’s precedent test to a genetic technology under development in Aotearoa New Zealand called single-sex offspring selection (SSOS). Single-sex offspring selection aims to control rat populations that harm native species either by producing primarily male litters or, by rendering females infertile, through a gene drive.